When proteins or other sensitive biomolecules need to be conjugated, polyethyleneglycol (PEG) linkers are a great choice. They provide hydrophilicity and maintain separation between conjugated molecules. This linker based on PEG4, has a length of 14Å (1.4 nm). Heterobifunctional linkers carrying different reactive groups can be used to prepare cross-conjugates between different molecules. The maleimide functional group is especially useful because they can label a site on a protein specifically. Most proteins have limited numbers of cysteine residues that selectively react with maleimides. Alkyne group can be then conjugated with azides in a selective copper-catalyzed process, CuAAc (copper-catalyzed alkyne azide cycloaddition).
CAS Number
1262681-30-0
Mass Spec M+ Shift after Conjugation
311.3
Purity
95% (by 1H NMR and HPLC-MS).
Molecular Formula
C15H21NO6
Molecular Weight
311.33 kDa
Product Form
Yellow oil.
Solubility
Good in water, DMF, and DMSO.
Storage
Shipped at room temperature. Upon delivery, store in the dark at -20°C. Avoid prolonged exposure to light. Desiccate.
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
