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Anti-CTLA4 Antibody

Mouse monoclonal (KT50) antibody to CTLA4 from Absea Biotechnology (030509C07).
Name: Anti-CTLA4 Antibody
Description: Mouse monoclonal (KT50) antibody to CTLA4.
Applications: ELISA, WB 
Reactivity: Human
Immunogen: Recombinant human CTLA-4.
Host: Mouse
Clonality: Monoclonal
Clone: KT50
Isotype: IgG2a
Conjugate: Unconjugated
Purification: IgG is purified through a Protein A column.
Concentration: 1 mg/ml
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
Tissue Specificity: Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation.
Involvement in Disease: Systemic lupus erythematosus: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

Diabetes mellitus, insulin-dependent, 12: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

Celiac disease 3: A multifactorial, chronic disorder of the small intestine caused by intolerance to gluten. It is characterized by immune-mediated enteropathy associated with failed intestinal absorption, and malnutrition. In predisposed individuals, the ingestion of gluten-containing food such as wheat and rye induces a flat jejunal mucosa with infiltration of lymphocytes.

Autoimmune lymphoproliferative syndrome 5: An autosomal dominant primary immunodeficiency characterized by severe autoimmunity, infiltration of non-lymphoid organs, such as the intestine, lungs and brain, by hyperactive T cells and B cells, autoimmune cytopenias, and hypogammaglobulinemia in early childhood.
Post-Translational Modification: N-glycosylation is important for dimerization.
Cellular Location: Cell membrane.

Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalisation;.
UniProt: P16410
Gene ID: 1493
Synonyms: ALPS5 Antibody
CD Antibody
CD 152 Antibody
CD152 Antibody
CD152 antigen Antibody
CD152 isoform Antibody
Celiac disease 3 Antibody
CELIAC3 Antibody
CTLA 4 Antibody
CTLA-4 Antibody
CTLA4_HUMAN Antibody
Cytotoxic T cell associated 4 Antibody
Cytotoxic T lymphocyte antigen 4 Antibody
Cytotoxic T lymphocyte associated 4 Antibody
Cytotoxic T lymphocyte associated 4, soluble isoform, included Antibody
Cytotoxic T lymphocyte associated antigen 4 Antibody
Cytotoxic T lymphocyte associated antigen 4 short spliced form Antibody
Cytotoxic T lymphocyte associated protein 4 Antibody
Cytotoxic T lymphocyte associated serine esterase 4 Antibody
Cytotoxic T lymphocyte protein 4 Antibody
Cytotoxic T-lymphocyte protein 4 Antibody
Cytotoxic T-lymphocyte-associated antigen 4 Antibody
GRD4 Antibody
GSE Antibody
ICOS Antibody
IDDM12 Antibody
insulin-dependent diabetes mellitus 12 Antibody
Ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4 Antibody
OTTHUMP00000216623 Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blotting result.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
start icons start icons start icons start icons start icons (2)
Total Citations (3)
Description: Mouse monoclonal (BNI3) antibody to CD152.
Application: FC, IP, IHC-Fr, ICC
Host: Mouse
Isotype: IgG2a
Reactivity: Human

£176





start icons start icons start icons start icons start icons (2)
Total Citations (3)
Description: Mouse monoclonal (BNI3) antibody to CD152.
Application: FC, IP, IHC-Fr, ICC
Host: Mouse
Isotype: IgG2a
Reactivity: Human

£176





Total Citations (2)
Description: Rabbit polyclonal antibody to CTLA4.
Application: WB
Host: Rabbit
Isotype: IgG
Reactivity: Human

£148 – £372

Description: Rabbit polyclonal antibody to CTLA4
Application: ELISA, ICC, IF, IHC, IP, WB
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide taken within amino acid region 150-200 on human CTLA4 protein.

£372

Please Note: Anti-CTLA4 Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | 030509C07
Size Price Quantity
100µg £178
200µg £259
1mg £682

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Lead Time: Currently 4-6 Days
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe