|Description:||Mouse monoclonal (KT50) antibody to CTLA4.|
|Immunogen:||Recombinant human CTLA-4.|
|Purification:||IgG is purified through a Protein A column.|
|Formulation:||Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.|
|Storage:||Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.|
|Function:||Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.|
|Tissue Specificity:||Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation.|
|Involvement in Disease:||Systemic lupus erythematosus: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Diabetes mellitus, insulin-dependent, 12: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Celiac disease 3: A multifactorial, chronic disorder of the small intestine caused by intolerance to gluten. It is characterized by immune-mediated enteropathy associated with failed intestinal absorption, and malnutrition. In predisposed individuals, the ingestion of gluten-containing food such as wheat and rye induces a flat jejunal mucosa with infiltration of lymphocytes.
Autoimmune lymphoproliferative syndrome 5: An autosomal dominant primary immunodeficiency characterized by severe autoimmunity, infiltration of non-lymphoid organs, such as the intestine, lungs and brain, by hyperactive T cells and B cells, autoimmune cytopenias, and hypogammaglobulinemia in early childhood.
|Post-Translational Modification:||N-glycosylation is important for dimerization.|
|Cellular Location:||Cell membrane.
Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalisation;.
CD 152 Antibody
CD152 antigen Antibody
CD152 isoform Antibody
Celiac disease 3 Antibody
CTLA 4 Antibody
Cytotoxic T cell associated 4 Antibody
Cytotoxic T lymphocyte antigen 4 Antibody
Cytotoxic T lymphocyte associated 4 Antibody
Cytotoxic T lymphocyte associated 4, soluble isoform, included Antibody
Cytotoxic T lymphocyte associated antigen 4 Antibody
Cytotoxic T lymphocyte associated antigen 4 short spliced form Antibody
Cytotoxic T lymphocyte associated protein 4 Antibody
Cytotoxic T lymphocyte associated serine esterase 4 Antibody
Cytotoxic T lymphocyte protein 4 Antibody
Cytotoxic T-lymphocyte protein 4 Antibody
Cytotoxic T-lymphocyte-associated antigen 4 Antibody
insulin-dependent diabetes mellitus 12 Antibody
Ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4 Antibody
|Information:||Target information shown above is from the UniProt Consortium.|