Anti-cTnI Antibody (HRP)
Mouse monoclonal (KT142) antibody to cTnI (HRP) from Absea Biotechnology (116808G02H).
|Name:||Anti-cTnI Antibody (HRP)|
|Description:||Mouse monoclonal (KT142) antibody to cTnI (HRP).|
|Immunogen:||Purified human cardiac troponin I.|
|Purification:||IgG is purified through a Protein A column and labelled with horseradish peroxidase.|
|Concentration:||1 mg/ml in PBS containing 0.01% thimerosal as a preservative.|
|Storage:||4 °C for 1 month, -20 °C or -80°C in aliquots. Avoid repeated freeze/thaw cycles.|
|Function:||Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.|
|Involvement in Disease:||Cardiomyopathy, familial hypertrophic 7: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Cardiomyopathy, familial restrictive 1: A heart disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.
Cardiomyopathy, dilated 2A: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Cardiomyopathy, dilated 1FF: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
|Sequence Similarities:||Belongs to the troponin I family.|
|Post-Translational Modification:||Phosphorylated at Ser-42 and Ser-44 by PRKCE; phosphorylation increases myocardium contractile dysfunction (By similarity). Phosphorylated at Ser-23 and Ser-24 by PRKD1; phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-31. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T).|
|Synonyms:||cardiac muscle Antibody
Cardiac Troponin I Antibody
cardiomyopathy, dilated 2A (autosomal recessive) Antibody
Cardiomyopathy, familial hypertrophic, 7, included Antibody
Familial hypertrophic cardiomyopathy 7 Antibody
TNN I3 Antibody
TNNC 1 Antibody
Troponin I Antibody
Troponin I cardiac Antibody
Troponin I cardiac muscle Antibody
Troponin I cardiac muscle isoform Antibody
Troponin I type 3 cardiac Antibody
troponin I, cardiac 3 Antibody
Ttroponin I type 3 (cardiac) Antibody
|Information:||Target information shown above is from the UniProt Consortium.|
Sandwich ELISA using KT143 coated plate and HRP conjugated KT142.
Western blotting result.
Please Note: Anti-cTnI Antibody (HRP) is for research use only. It is not intended for diagnostic of therapeutic use.