Anti-CXCL7 / PBP Antibody [C06-A43] (Biotin) (A279939)

Anti-CXCL7 / PBP Antibody [C06-A43] (Biotin)

Mouse monoclonal [C06-A43] antibody to CXCL7 / PBP (Biotin).

This antibody recognises C-X-C motif chemokine 7 (CXCL7), also known as Platelet Basic Protein, a platelet derived growth factor belonging to the C-X-C subfamily of chemokines. Expression of CXCL7 is largely restricted to platelets where it is produced as an inactive precursor. Upon tissue injury or infection, CXCL7 is one of the first chemokines to appear at the focal sites to mediate neutrophil recruitment after it has been modified by a series of cleavage and activation steps. CXCL7 mediates neutrophil recruitment through binding of its receptors CXCR1 or CXCR2.CXCL7 has been noted as playing important roles in tumorigenesis and has been associated with the proliferation and metastasis of a range of tumor types. Serum CXCL7 serves as a diagnostic biomarker in colorectal cancer, lung cancer and renal cell carcinoma samples (Li et al. 2019, Kinouchi et al. 2017, Du et al. 2018) suggesting that serum CXCL7 may be a sensitive and specific biomarker for the diagnosis of these cancer types.The biotinylated Mouse anti Human CXCL7 antibody, clone C06-4A3 (MCA6225B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CXCL7 antibody, clone C11-5G10 (MCA6224GA) as the capture antibody.

ELISA: 1 µg/ml

Human

E. coli derived recombinant human full length CXCL7 (Ala59-Asp128).

Mouse

Monoclonal

C06-A43

Protein G affinity chromatography of tissue culture supernatant.

100 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.

Mouse anti Human CXCL7 antibody, clone C11-5G10, recognizes C-X-C motif chemokine 7 (CXCL7), also known as Platelet Basic Protein, a platelet derived growth factor belonging to the C-X-C subfamily of chemokines. Expression of CXCL7 is largely restricted to platelets where it is produced as an inactive precursor. Upon tissue injury or infection, CXCL7 is one of the first chemokines to appear at the focal sites to mediate neutrophil recruitment after it has been modified by a series of cleavage and activation steps. CXCL7 mediates neutrophil recruitment through binding of its receptors CXCR1 or CXCR2.CXCL7 has been noted as playing important roles in tumorigenesis and has been associated with the proliferation and metastasis of a range of tumor types (Brown et al. 2017). Serum CXCL7 serves as a diagnostic biomarker in colorectal cancer, lung cancer and renal cell carcinoma samples (Li et al. 2019, Kinouchi et al. 2017, Du et al. 2018) suggesting that serum CXCL7 may be a sensitive and specific biomarker for the diagnosis of these cancer types.The biotinylated Mouse anti Human CXCL7 antibody, clone C06-4A3 (MCA6225B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CXCL7 antibody, clone C11-5G10 (MCA6224GA) as the capture antibody.

This product is for research use only. It is not intended for diagnostic or therapeutic use.