Anti-CYP1B1 Antibody (A283717)

Anti-CYP1B1 Antibody

Rabbit polyclonal antibody to CYP1B1.

This antibody recognises cytochrome P450 1B1, also known as CYPIB1. It is a member of the cytochrome P450 superfamily of enzymes. It catalyses the hydroxylation of 17-ß-oestradiol at the C4 position (Jefcoate et al. 2000, Potter et al. 2002). A number of Cytochrome P450 1B1 mutations are associated with primary congenital glaucoma.

WB, IF

IF: 1:50 - 1:200, WB: 1:500 - 1:2,000

Human

Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human cytochrome P450 1B1.

MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFRE

Rabbit

Polyclonal

IgG

Unconjugated

Approximately 62 kDa in various cell and tissue lysates under reducing conditions

Liquid

Supplied in Phosphate Buffered Saline with 50% Glycerol and 0.02% Sodium Azide.

Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti cytochrome P450 1B1 antibody recognizes cytochrome P450 1B1, also known as CYPIB1. It is a member of the cytochrome P450 superfamily of enzymes. It catalyses the hydroxylation of 17-ß-oestradiol at the C4 position (Jefcoate et al. 2000, Potter et al. 2002). A number of Cytochrome P450 1B1 mutations are associated with primary congenital glaucoma (Rauf et al. 2016).

Aryl hydrocarbon hydroxylase, CP1B, CP1B1_HUMAN, CYPIB1, Cytochrome P450 1B1, Cytochrome P450 family 1 subfamily B polypeptide 1, Cytochrome P450 subfamily I (dioxin inducible) polypeptide 1 (glaucoma 3 primary infantile), Flavoprotein linked monooxygenase, GLC3A, Microsomal monooxygenase, P4501B1, Xenobiotic monooxygenase