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Anti-Cystatin-C Antibody

 
Mouse monoclonal (KT145) antibody to Cystatin-C from Absea Biotechnology (0611210C10).
Overview
Name: Anti-Cystatin-C Antibody
Description: Mouse monoclonal (KT145) antibody to Cystatin-C.
Applications: WB, ELISA, sELISA
Reactivity: Human
Immunogen: Purified native human Cystatin-C.
Host: Mouse
Clonality: Monoclonal
Clone: KT145
Isotype: IgG2a
Conjugate: Unconjugated
Purification: IgG is purified through a Protein A column.
Concentration: 1 mg/ml in PBS containing 0.09% sodium azide as a preservative.
Storage: 4 °C for 1 month, -20 °C or -80°C in aliquots. Avoid repeated freeze/thaw cycles.

Target
Function: As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.
Tissue Specificity: Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in various body fluids, such as the cerebrospinal fluid and plasma. Expressed in highest levels in the epididymis, vas deferens, brain, thymus, and ovary and the lowest in the submandibular gland.
Involvement in Disease: Amyloidosis 6: A hereditary generalized amyloidosis due to cystatin C amyloid deposition. Cystatin C amyloid accumulates in the walls of arteries, arterioles, and sometimes capillaries and veins of the brain, and in various organs including lymphoid tissue, spleen, salivary glands, and seminal vesicles. Amyloid deposition in the cerebral vessels results in cerebral amyloid angiopathy, cerebral hemorrhage and premature stroke. Cystatin C levels in the cerebrospinal fluid are abnormally low.

Macular degeneration, age-related, 11: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.
Sequence Similarities: Belongs to the cystatin family.
Post-Translational Modification: The Thr-25 variant is O-glycosylated with a core 1 or possibly core 8 glycan. The signal peptide of the O-glycosylated Thr-25 variant is cleaved between Ala-20 and Val-21.
Cellular Location: Secreted.
UniProt: P01034
Gene ID: 1471
Synonyms: AD 8 Antibody
AD8 Antibody
Amyloid angiopathy and cerebral hemorrhage Antibody
ARMD11 Antibody
bA218C14.4 Antibody
bA218C14.4 (cystatin C) Antibody
Cst 3 Antibody
Cst3 Antibody
CST3 protein Antibody
Cystatin 3 Antibody
Cystatin C Antibody
Cystatin-3 Antibody
Cystatin3 Antibody
CystatinC Antibody
CYTC_HUMAN Antibody
Gamma trace Antibody
Gamma-trace Antibody
HCCAA Antibody
MGC117328 Antibody
Neuroendocrine basic polypeptide Antibody
Post gamma globulin Antibody
Post-gamma-globulin Antibody
Information: Target information shown above is from the UniProt Consortium.

Images
Sandwich ELISA - Anti-Cystatin-C Antibody from Absea Biotechnology (0611210C10) - Antibodies.com
Sandwich ELISA using KT145 coated plate and HRP conjugated KT144.
Western Blot - Anti-Cystatin-C Antibody from Absea Biotechnology (0611210C10) - Antibodies.com
Western blotting result.


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Please Note: Anti-Cystatin-C Antibody is for research use only. It is not intended for diagnostic of therapeutic use.
Antibodies.com | 0611210C10
Size Price Quantity
100µg £178
200µg £259
1mg £682

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