Anti-DcR1 Antibody [2B8] (PE) (A279189)

Anti-DcR1 Antibody [2B8] (PE)

Mouse monoclonal [2B8] antibody to DcR1 (PE).

This antibody recognises human CD263, a ~60 kDa cell surface protein, which is otherwise known as decoy receptor 1 (DcR1). CD263 is a member of the tumour necrosis factor (TNF) receptor superfamily that binds to TNF-related apoptosis inducing ligand (TRAIL). As the receptor does not possess cytoplasmic death domains it cannot induce apoptosis, but instead plays an important role in inhibiting TRAIL-induced apoptosis. CD263 is expressed in normal tissues including heart, skeletal tissues and peripheral blood neutrophils, but weakly expressed in tumour cells.The 2B8 antibody does not inhibit DcR1 (CD263) inhibitory function in TRAIL-induced apoptosis.

Flow Cytometry: Neat - 1:10, Use 10µl of the suggested working dilution to label 1x10⁶ cells in 100µl.

Human

DcR1-Fc chimaeric protein.

Mouse

Monoclonal

2B8

IgG1

PE

Excitation: 565nm, Emission: 578nm

Reconstitution dependent.

Lyophilized

Reconstitute with 1 ml of distilled water.

Supplied in Phosphate Buffered Saline with 1% BSA, 5% Sucrose, and 0.09% Sodium Azide.

Store undiluted at 4°C. Do not freeze! This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.

Mouse anti Human CD263 antibody, clone 2B8 recognizes human CD263, a ~60 kDa cell surface protein, which is otherwise known as decoy receptor 1 (DcR1). CD263 is a member of the tumour necrosis factor (TNF) receptor superfamily that binds to TNF-related apoptosis inducing ligand (TRAIL). As the receptor does not possess cytoplasmic death domains it cannot induce apoptosis, but instead plays an important role in inhibiting TRAIL-induced apoptosis. CD263 is expressed in normal tissues including heart, skeletal tissues and peripheral blood neutrophils, but weakly expressed in tumour cells.The 2B8 antibody does not inhibit DcR1 (CD263) inhibitory function in TRAIL-induced apoptosis.

Antagonist decoy receptor for TRAIL/Apo 2L, CD263, Cytotoxic TRAIL receptor 3, DCR1 TNFR, Decoy Receptor 1, Decoy TRAIL receptor without death domain, LIT, Lymphocyte inhibitor of TRAIL, MGC149501, MGC149502, TNF related apoptosis inducing ligand receptor 3, TNF-re ated apoptosis inducing ligand receptor 3, TNFRSF10C, TRAIL R3, TRAIL receptor 3, TRAILR3, TRID, Tumor necrosis factor receptor superfamily member 10C, Tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain

This product is for research use only. It is not intended for diagnostic or therapeutic use.