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Anti-DENND1A Antibody

Rabbit polyclonal antibody to DENND1A from ABclonal (A10758).
Name: Anti-DENND1A Antibody
Description: Rabbit polyclonal antibody to DENND1A.
Applications: WB
Dilutions: WB: 1:500 - 1:2000.
Reactivity: Human
Immunogen: Recombinant protein of human DENND1A.
Protein Length: 1009 (559)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity).
Post-Translational Modification: Phosphorylated on serine and/or threonine in an Akt-dependent manner. Phosphorylation probably regulates the guanine nucleotide exchange factor (GEF) activity, possibly by disrupting an intramolecular interaction between the DENN domain and the C-terminus of the protein, thereby relieving the autoinhibition.
Cellular Location: Cytoplasmic vesicle > Clathrin-coated vesicle membrane. Cell junction > Synapse > Presynaptic cell membrane.

Associates to membranes via lipid-binding activity.
UniProt: Q8TEH3
Gene ID: 57706
Synonyms: Connecdenn Antibody
Connecdenn 1 Antibody
DEN1A_HUMAN Antibody
DENN domain-containing protein 1A Antibody
DENN/MADD domain containing 1A Antibody
FAM31A Antibody
FLJ21129 Antibody
FLJ38464 Antibody
KIAA1608 Antibody
OTTHUMP00000022090 Antibody
Protein FAM31A Antibody
RP11 230L22.3 Antibody
Information: Target information shown above is from the UniProt Consortium.
Description: Rabbit polyclonal antibody to DENND1A.
Application: WB, IHC, FC
Host: Rabbit
Isotype: IgG
Reactivity: Human

£243 – £372

Description: Rabbit Polyclonal Antibody to DENND1A
Application: ELISA, WB, IF
Host: Rabbit
Isotype: IgG
Immunogen: DENN/MADD domain containing 1A

£284





Please Note: Anti-DENND1A Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A10758
Size Price Quantity
50µl £148
100µl £243
200µl £372

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Lead Time: Currently 4-6 Days
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe