Anti-Desmoglein 3 Antibody [DSG3/2840] - BSA and Azide free (A251554)

Mouse monoclonal [DSG3/2840] antibody to Desmoglein 3 for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-Desmoglein 3 Antibody [DSG3/2840] - BSA and Azide free
Description
Mouse monoclonal [DSG3/2840] antibody to Desmoglein 3.
Specificity
This antibody recognizes a protein of 130kDa, identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis.
Applications
IHC-P
Dilutions
IHC-P: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment, around amino acids 379-491, human DSG3 protein. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
DSG3/2840
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Molecular Weight
130 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-Desmoglein 3 Antibody [DSG3/2840] (A248372).
Synonyms
130 kD pemphigus vulgaris antigen, 130 kDa pemphigus vulgaris antigen, Balding, Cadherin family member 6, CDHF 6, CDHF6, Desmoglein 3 precursor, Desmoglein-3, Desmoglein3, DKFZp686P23184, DSG 3, DSG3, DSG3_HUMAN, Pemphigus vulgaris antigen, PVA
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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