Specificity
Mouse anti diphtheria toxin A antibody, clone 8G2 recognizes diphtheria toxin (DT), secreted by certain strains of Corynebacterium diphtheriae. DT catalyzes the ADP-ribosylation of eukaryotic aminoacyl-transferase II (EF-2) using NAD as a substrate. This reaction forms the basis for its toxicity toward eukaryotic organisms. The toxin is secreted as a single polypeptide chain of about 63kDa, it is then processed to form A and B fragments both of which appear to be required for toxicity.Mouse anti diphtheria toxin A antibody, clone 8G2 recognizes both the free and bound A subunit of diphtheria toxin.
