Anti-DLL4 Antibody [HMD4-2] (A280629)

Anti-DLL4 Antibody [HMD4-2]

Hamster monoclonal [HMD4-2] antibody to DLL4.

This antibody recognises mouse Delta-like protein 4 (DLL4), one of the five major ligands of the Notch signaling pathway, activated through the binding of specific ligands to the Notch receptors Notch 1-4.DLL4 is expressed by vascular endothelium, and plays a vital role in embryonic vascular development. DLL4 signaling has been shown to play a role in the angiogenesis of clear-cell renal tumors, and pancreatic, bladder and colonic cancer. DLL4 expression in endothelium cells, can be up-regulated by vascular endothelial growth factor (VEGF) and basic-FGF, and by HIF1 alpha, and that blockade of DLL4 inhibits tumor growth by promoting non-productive angiogenesis.

IHC-P, IHC-Fr, Flow Cytometry, Functional Assays

Use 10µl of the suggested working dilution to label 1x10⁶ cells in 100µl.

Mouse

Recombinant mouse DLL4.

Hamster

Monoclonal

HMD4-2

IgG

Unconjugated

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Hamster anti Mouse Delta-Like Protein 4 antibody, clone HMD4-2 recognizes mouse Delta-like protein 4 (DLL4), one of the five major ligands of the Notch signaling pathway, activated through the binding of specific ligands to the Notch receptors Notch 1-4.DLL4 is expressed by vascular endothelium, and plays a vital role in embryonic vascular development. DLL4 signaling has been shown to play a role in the angiogenesis of clear-cell renal tumors, and pancreatic, bladder and colonic cancer. DLL4 expression in endothelium cells, can be up-regulated by vascular endothelial growth factor (VEGF) and basic-FGF, and by HIF1 alpha, and that blockade of DLL4 inhibits tumor growth by promoting non-productive angiogenesis.

AOS6, Delta 4, delta 4 precursor, Delta ligand 4, delta ligand 4 precursor, Delta like 4, Delta like 4 homolog, Delta like 4 protein, Delta like canonical Notch ligand 4, Delta like protein 4, Delta-like 4 (Drosophila), Delta-like protein 4, Delta4, DLL 4, DLL4_HUMAN, Drosophila Delta homolog 4, hdelta2, Homeobox protein DLL-4, MGC126344, Notch ligand delta 2, Notch ligand DLL4, Notch ligand DLL4 precursor, XDLL-4