Anti-ELOVL4 Antibody (Biotin)
Rabbit polyclonal antibody to ELOVL4 (Biotin) from FabGennix (ELOVL4-412-BIOTIN).
|Name:||Anti-ELOVL4 Antibody (Biotin)|
|Description:||Rabbit polyclonal antibody to ELOVL4 (Biotin)|
|Applications:||ELISA, IHC, IP, WB|
|Dilutions:||Western Blot: 1:500|
|Reactivity:||Human, Mouse, Rat|
|Immunogen:||Synthetic peptide corresponding to internal sequence amino acids 107-121 of Human ELOVL4.|
|Concentration:||0.6 µg/µl in antibody stabilization buffer|
|Storage:||-20⁰C for long term storage|
|Function:||Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.|
|Tissue Specificity:||Expressed in the retina and at much lower level in the brain. Ubiquitous, highest expression in thymus, followed by testis, small intestine, ovary, and prostate. Little or no expression in heart, lung, liver, or leukocates.|
|Involvement in Disease:||Stargardt disease 3: A common hereditary macular degeneration. It is characterized by decreased central vision, atrophy of the macula and underlying retinal pigment epithelium, and frequent presence of prominent flecks in the posterior pole of the retina.
Ichthyosis, spastic quadriplegia, and mental retardation: A severe autosomal recessive disorder characterized by ichthyosis apparent from birth, profound psychomotor retardation with essentially no development, spastic quadriplegia, and seizures.
Spinocerebellar ataxia 34: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA34 is an autosomal dominant form characterized by the association of progressive cerebellar ataxia with erythrokeratodermia variabilis.
|Sequence Similarities:||Belongs to the ELO family. ELOVL4 subfamily.|
|Cellular Location:||Endoplasmic reticulum membrane.|
|Synonyms:||3-keto acyl-CoA synthase ELOVL4 Antibody
Cancer/testis antigen 118 Antibody
Elongation of very long chain fatty acids (FEN1/Elo2 SUR4/Elo3 yeast) like 4 Antibody
Elongation of very long chain fatty acids like 4 Antibody
Elongation of very long chain fatty acids protein 4 Antibody
ELOV L4 Antibody
ELOVL 4 Antibody
Stargardt disease 3 Antibody
Stargardt disease 3 autosomal dominant Antibody
STGD 2 Antibody
STGD 3 Antibody
|Information:||Target information shown above is from the UniProt Consortium.|
Please Note: Anti-ELOVL4 Antibody (Biotin) is for research use only. It is not intended for diagnostic of therapeutic use.