Anti-ERG Antibody [ERG/6980] (A314924)

$765

Mouse monoclonal [ERG/6980] antibody to ERG for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-ERG Antibody [ERG/6980]
Description
Mouse monoclonal [ERG/6980] antibody to ERG.
Specificity
ERG (ETS-related gene) is a proto-oncogene, a member of the ETS family of transcription factors. The ERG gene encodes for a nuclear protein, also called ERG, which is involved in hematopoietic and endothelial development. ERG remains constitually expressed in endothelial cells in blood and lymphatic vessels, and in bone marrow stem cells. ERG is expressed in virtually all endothelial neoplasms including hemangioendothelioma, angiosarcoma and Kaposi sarcoma. ERG is overexpressed secondary to gene rearrangement in cases of prostate adenocarcinoma, gastrointestinal stromal tumor, synovial sarcoma, meningioma, epithelioid sarcoma, malignant rhabdoid tumor, acute myeloid leukemia and blastic extramedullary myeloid tumor, and rarely Ewing sarcoma / primitive peripheral neuroectodermal tumor, chondrosarcoma, osteosarcoma, and rhabdomyosarcoma. For the identification of endothelial differentiation ERG seems more sensitive and specific than any other marker. Moreover, the interpretation is often easier due to the nuclear reaction, which also allows for double stains with cytoplasmic markers like podoplanin. Among carcinomas, ERG is highly specific for prostate, while the sensitivity is moderate.
Applications
IHC-P
Positive Control
Human tonsil, Ewing sarcoma or prostate adenocarcinoma tissues.
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment (around Amino Acids 450 to 479) (C-terminus) of human ERG. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
ERG/6980
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
55 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
Avian erythroblastosis virus E-26 (v-ets) oncogene related, D030036I24Rik, Erg 3, ERG/EWS fusion gene, included, ERG/FUS fusion gene, included, ERG/TMPSSR2 fusion gene, included, ERG1, included, ERG2, included, ERG_HUMAN, ets related, ETS-related gene, KCNH2, Oncogene ERG, p55, TMPRSS2/ERG fusion, Transcriptional regulator ERG, transcriptional regulator ERG (transforming protein ERG), Transforming protein ERG, v ets avian erythroblastosis virus E26 oncogene, v ets avian erythroblastosis virus E26 oncogene related, v ets erythroblastosis virus E26 oncogene homolog, v ets erythroblastosis virus E26 oncogene like, v ets erythroblastosis virus E26 oncogene like isoform 2, v-ets erythroblastosis virus E26 oncogene, v-ets erythroblastosis virus E26 oncogene homolog (avian), V-ets erythroblastosis virus E26 oncogene like (Avian), isoform CRA_e
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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