Anti-Estrogen Receptor beta 2 Antibody [57/3] (A248488)

Anti-Estrogen Receptor beta 2 Antibody [57/3]

Mouse monoclonal [57/3] antibody to Estrogen Receptor beta 2.

This antibody recognizes the estrogen receptor beta 2 isoform, expressed in cell nuclei of a range of human tissues including ovary, placenta, testis and vas deferens. No cross-reactivity is seen with estrogen receptor beta 1 isoform. This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members.

Flow Cytometry, IF, WB, IHC-P

Flow Cytometry: 2-4 µg/million cells, IF: 2-4 µg/ml, WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human

Synthetic peptide corresponding to the C terminus of human Estrogen Receptor beta 2 isomer.

CGMKMETLLPEATMEQ

Mouse

Monoclonal

57/3

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

59 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Estrogen Receptor beta 2 Antibody [57/3] - BSA and Azide free (A251670).