Anti-Estrogen Receptor beta 5 Antibody [PPG5/25] (A248489)

Anti-Estrogen Receptor beta 5 Antibody [PPG5/25]

Mouse monoclonal [PPG5/25] antibody to Estrogen Receptor beta 5.

This antibody specifically recognizes human estrogen receptor beta 5 (ERB5), a splice variant of the nuclear receptor hormone ER beta (ESR2), shown to exist in at least five isoforms (ERB1-ERB5). No cross-reactivity is seen with estrogen receptor beta 1 or 2 isoform. This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members.

IF, WB, IHC-P

IF: 2-4 µg/ml, WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human

Tuberculin conjugated synthetic peptide, derived from the C-terminus of human Estrogen Receptor beta 5.

LLSHVRHARYAP

Mouse

Monoclonal

PPG5/25

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

59 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Estrogen Receptor beta 5 Antibody [PPG5/25] - BSA and Azide free (A251671).