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Anti-Factor I Antibody

 
Mouse monoclonal (KT22) antibody to Factor I from Absea Biotechnology (010112A05).
Overview
Name: Anti-Factor I Antibody
Description: Mouse monoclonal (KT22) antibody to Factor I.
Applications: ELISA
Reactivity: Human
Immunogen: Purified Factor I from human blood.
Host: Mouse
Clonality: Monoclonal
Clone: KT22
Isotype: IgG2b
Conjugate: Unconjugated
Purification: IgG is purified through a Protein A column.
Concentration: 1 mg/ml in PBS containing 0.09% sodium azide as a preservative.
Storage: 4 °C for 1 month, -20 °C or -80°C in aliquots. Avoid repeated freeze/thaw cycles.

Target
Function: Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively.
Tissue Specificity: Plasma.
Involvement in Disease: Hemolytic uremic syndrome atypical 3: An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.

Complement factor I deficiency: Autosomal recessive condition associated with a propensity to pyogenic infections.

Macular degeneration, age-related, 13: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.
Sequence Similarities: Belongs to the peptidase S1 family.
Cellular Location: Secreted > Extracellular space.
UniProt: P05156
Gene ID: 3426
Synonyms: AHUS3 Antibody
ARMD13 Antibody
C3b INA Antibody
C3b inactivator Antibody
C3B/C4B inactivator Antibody
C3BINA Antibody
CFAI_HUMAN Antibody
Cfi Antibody
Complement component I Antibody
Complement control protein factor I Antibody
Complement factor I Antibody
Complement factor I heavy chain Antibody
Complement factor I light chain Antibody
F1 Antibody
FactorI Antibody
FI Antibody
I factor Antibody
IF Antibody
KAF Antibody
Konglutinogen activating factor Antibody
Light chain of factor I Antibody
OTTHUMP00000219728 Antibody
OTTHUMP00000221928 Antibody
Information: Target information shown above is from the UniProt Consortium.

Research Areas

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Please Note: Anti-Factor I Antibody is for research use only. It is not intended for diagnostic of therapeutic use.
Antibodies.com | 010112A05
Size Price Quantity
100µg £178
200µg £259
1mg £682

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