Recombinant Anti-Ferritin Heavy Chain Antibody [FTH/8700R] - BSA and Azide free (A316337)

$765

Recombinant rabbit monoclonal [FTH/8700R] antibody to Ferritin Heavy Chain for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-Ferritin Heavy Chain Antibody [FTH/8700R] - BSA and Azide free
Description
Recombinant rabbit monoclonal [FTH/8700R] antibody to Ferritin Heavy Chain.
Specificity
Mammalian ferritins consist of 24 subunits made up of 2 types of poly-peptide chains, ferritin heavy chain and ferritin light chain, which each have unique functions. Ferritin heavy chains catalyze the first step in iron storage, the oxidationof FeI(II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe(III). The most prominent role of mammalian ferritins is to provide iron-buffering capacity to cells. In addition to iron buffering, heavy chain ferritin is also involved in the regulation of thymidine biosynthesis via increased expression of cytoplasmic serine hydroxymethyltransferase, which is a limiting factor in thymidylate synthesis in MCF-7 cells. Light chain ferritin is involved in cataracts by at least two mechanisms: hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed; and oxidative stress, an important factor in the development of aging-related cataracts.
Applications
IHC-P
Positive Control
Human liver tissue. Liver tissue lysate.
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant human FTH1 protein fragment (around Amino Acids 58-180). The exact sequence is proprietary.
Host
Rabbit
Clonality
Monoclonal
Clone ID
FTH/8700R
Isotype
IgG
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Molecular Weight
21 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
Apoferritin, Cell proliferation inducing gene 15 protein, Cell proliferation-inducing gene 15 protein, F HC, Ferritin H subunit, Ferritin heavy polypeptide 1, FHC, FRIH, FRIH_HUMAN, FTH, FTH 1, FTH1, FTH1 protein, FTHL 6, FTHL6, Iron overload autosomal dominant, MGC104426, N-terminally processed, OK/SW-cl.84, PIG 15, PIG15, Placenta immunoregulatory factor, PLIF, Proliferation inducing gene 15 protein, Proliferation inducing protein 15
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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