Anti-Fibrinogen alpha Chain Antibody [UC45] (A248539)

Anti-Fibrinogen alpha Chain Antibody [UC45]

Mouse monoclonal [UC45] antibody to Fibrinogen alpha Chain.

The plasma glycoprotein Fibrinogen is synthesized in the liver and comprises three structurally different subunits: . Fibrinogen is important in platelet aggregation, the final step of the coagulation cascade (i.e. the formation of Fibrin) and determination of plasma viscosity and erythrocyte aggregation. It is both constitutively expressed and inducible during an acute phase reaction. Hemostasis following tissue injury deploys essential plasma procoagulants (Prothrombin and Factors X, IX, V and VIII), which are involved in a blood coagulation cascade leading to the formation of insoluble Fibrin clots and the promotion of platelet aggregation. Following vascular injury, Fibrinogen is cleaved by Thrombin to form Fibrin, which is the most abundant component of blood clots. The cleavage products of Fibrinogen regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types.

ELISA, Flow Cytometry, IF

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml

Human

Human acute monoblastic leukemia cells.

Mouse

Monoclonal

UC45

IgM

Unconjugated

Protein A/G chromatography.

200 µg/ml

30 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Fibrinogen alpha Chain Antibody [UC45] - BSA and Azide free (A254302).

Ac1873, Fba5e, FGA, Fib, Fib2, FIBA_HUMAN, Fibrinogen, A alpha polypeptide, Fibrinogen--alpha polypeptide chain, Fibrinopeptide A