Recombinant Anti-Filaggrin Antibody [rFLG/1945] (A277886)

Recombinant mouse monoclonal [rFLG/1945] antibody to Filaggrin for WB and IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-Filaggrin Antibody [rFLG/1945]
Description
Recombinant mouse monoclonal [rFLG/1945] antibody to Filaggrin.
Specificity
Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules.Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.
Applications
WB, IHC-P
Dilutions
WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment, around amino acids 198-288, of human Filaggrin. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
rFLG/1945
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
26-45 kDa (Processed) / 350 kDa (Profilaggrin)
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Filaggrin Antibody [rFLG/1945] - BSA and Azide free (A278474).
Synonyms
ATOD2, Epidermal filaggrin, Filaggrin precursor, FILA_HUMAN, Fillagrin, FLG, Profilaggrin
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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