Recombinant Anti-FLI1 Antibody [FLI1/8318R] (A314968)

$765

Recombinant rabbit monoclonal [FLI1/8318R] antibody to FLI1 for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-FLI1 Antibody [FLI1/8318R]
Description
Recombinant rabbit monoclonal [FLI1/8318R] antibody to FLI1.
Specificity
Recognizes a protein of 51kDa, which is identified as FLI1. This protein, a member of the ETS family of DNA binding transcription factors, is involved in cellular proliferation and tumorigenesis. Ets-1 is the prototype member of a family of genes identified on the basis of homology to the v-Ets oncogene isolated from the E26 erythroblastosis virus. Members of the Ets gene family share a highly conserved carboxy-terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. Approximately 90% of Ewing s Sarcoma (EWS) / Primitive Neuroectodermal Tumors (PNET) have a specific translocation, t(11;22)(q24;q12), which results in fusion of EWS to Fli-1, and production of an EWS-Fli-1 fusion protein. Among normal tissues only endothelial cells and small lymphocytes express Fli-1. This protein is expressed in majority of vascular tumors including angiosarcomas, hemangioendotheliomas, hemangiomas, and Kaposi s Sarcomas. High sensitivity and specificity of Fli-1 equals to or exceeds that of the established vascular markers like CD31, CD34, and Factor VIII.
Applications
IHC-P
Positive Control
THP1 or Raji cells. Human tonsil, Ewing s sarcoma (EWS) or angiosarcoma.
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment (around Amino Acids 200-400) of human FLI1 protein. The exact sequence is proprietary.
Host
Rabbit
Clonality
Monoclonal
Clone ID
FLI1/8318R
Isotype
IgG
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A chromatography.
Concentration
200 µg/ml
Molecular Weight
51 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
ERGB transcription factor, Ewing Sarcoma breakpoint region 2, EWSR 2, EWSR2, FLI 1, FLI 1 proto oncogene, Fli-1 proto-oncogene, ETS transcription factor, FLI1 EWS fusion gene, FLI1 proto oncogene, FLI1_HUMAN, Friend leukemia integration 1 (FLI1) transcription factor, Friend leukemia integration 1 transcription factor, Friend leukemia virus integration 1, Proto-oncogene Fli-1, Sarcoma breakpoint region 2 (EWSR2), SIC 1, SIC1, Transcription factor ERGB, Viral integration region FLI1, Viral integration region FLI1, mouse, homolog of
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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