ULBP1 est un gène codé par le symbole ULBP1. Il est également connu sous le nom de: UL16-binding protein 1; ALCAN-beta; NKG2D ligand 1; N2DL-1; Retinoic acid early transcript 1I; N2DL1; RAET1I. ULBP1 a une masse de 28kDa et une longueur d'acide aminé de 244.
Nous proposons 1 des anticorps contre ULBP1, élevé dans Lapin, qui sont appropriés pour le IHC avec des échantillons dérivés de Humain.
Informations sur les Gènes et les Protéines
Résumé UniProt
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Résumé Entrez
The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene.
Spécificité tissulaire
Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.
Similitudes de séquence
Belongs to the MHC class I family.
Localisation cellulaire
Cell membrane. Endoplasmic reticulum.
In CMV-infected fibroblasts, detected in the endoplasmic reticulum/cis-Golgi.
