Mouse anti Rabbit GAPDH antibody, clone 6C5 recognizes glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a ~36 kDa multifunctional protein whose main function is to catalyse the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate, in conjunction with inorganic phosphate and nicotinamide adenine dinucleotide (NAD). This reaction is an important energy yielding step in carbohydrate metabolism. GAPDH has also been shown to translocate to the nucleus under a variety of stressors, most of which are associated with oxidative stress, whereby it mediates cell death. A further report has shown that GAPDH binds to several proteins that are responsible for neurodegenerative diseases, such as amyloid precursor protein and Huntingtin (Hara et al. 2006).
Applications
WB
Reactivity
Rabbit, Sheep, Vertebrates, Xenopus, Tube-nosed Bat, Porcine, Rat, African Green Monkey, Feline, Chicken, Crucian Carp, Canine, Human, Mouse
Immunogen
Rabbit muscle GAPDH.
Host
Mouse
Clonality
Monoclonal
Clone ID
6C5
Isotype
IgG1
Conjugate
DyLight® 800
Excitation: 771nm, Emission: 796nm
Purification
Protein A chromatography.
Concentration
1 mg/ml
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.
