Anti-Glucose Transporter GLUT4 Antibody [1F8] (A279106)

Anti-Glucose Transporter GLUT4 Antibody [1F8]

Mouse monoclonal [1F8] antibody to Glucose Transporter GLUT4.

This antibody recognises an epitope in the cytoplasmic region of Glucose transporter 4 (GLUT4), an insulin-regulated facilitative glucose transporter found in adipose tissue and striated muscle. When stimulated by insulin, GLUT4 translocates from intracellular stores to the cell surface, facilitating passive diffusion of circulating glucose into muscle and fat cells. GLUT4 is also stimulated to locate to the cell surface by muscle contraction, particularly in cardiac muscle. Mouse anti glucose transporter 4 antibody, clone 1F8 has been used successfully to demonstrate the localization of GLUT4 to the basolateral side of ductal structures in the rat submandibular salivary gland in formalin fixed, paraffin embedded material.

WB, IHC-P, IF, IP, IHC-Fr

Rat, Mouse, Monkey, Rabbit, Human, Pig

This antibody does not cross react with Dog

Partially purified vesicles containing insulin-responsive glucose transporter 4.

Mouse

Monoclonal

1F8

IgG1

Unconjugated

Protein G affinity chromatography of tissue culture supernatant.

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti glucose transporter 4 antibody, clone 1F8 originally raised against rat intracellular low density microsomes (James et al. 1987) recognizes an epitope in the cytoplasmic region of Glucose transporter 4 (GLUT4), an insulin-regulated facilitative glucose transporter found in adipose tissue and striated muscle. When stimulated by insulin, GLUT4 translocates from intracellular stores to the cell surface, facilitating passive diffusion of circulating glucose into muscle and fat cells. GLUT4 is also stimulated to locate to the cell surface by muscle contraction, particularly in cardiac muscle (James et al. 1988).Mouse anti glucose transporter 4 antibody, clone 1F8 has been used successfully to demonstrate the localization of GLUT4 to the basolateral side of ductal structures in the rat submandibular salivary gland in formalin fixed, paraffin embedded material (Cetik et al. 2014).

Glucose transporter GLUT 4, Glucose transporter type 4, Glucose transporter type 4 insulin responsive, GLUT 4, GLUT-4, GLUT4, GTR4_HUMAN, Insulin responsive glucose transporter type 4, insulin-responsive, kug, SLC 2A4, SLC2A4, solute carrier family 2 (facilitated glucose transporter) member 4, Solute carrier family 2 member 4, Solute carrier family 2, facilitated glucose transporter member 4