Recombinant Anti-GnRHR Antibody [GNRHR/2982R] (A248745)

Recombinant rabbit monoclonal [GNRHR/2982R] antibody to GnRHR for ELISA.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-GnRHR Antibody [GNRHR/2982R]
Description
Recombinant rabbit monoclonal [GNRHR/2982R] antibody to GnRHR.
Specificity
This antibody recognizes an epitope on the extracellular domain of gonadotropin releasing hormone (GnRH) receptor or luteinizing hormone receptor (LHCGR). Lutropin (also designated luteinizing hormone) plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Gonadotropin (also designated choriogonadotropin) production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone/choriogonadotropin receptor. GnRH receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular and intracellular loops characteristic of G-protein coupled receptors. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinizing hormone (LH) as well as follicle-stimulating hormone (FSH). GnRH influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of GnRH on breast carcinoma correlates in part to the degree of tumor differentiation. GnRH-positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women. GnRH is present in luteal and granulosa cells as well as in ovarian cell membrane preparations.
Applications
ELISA
Reactivity
Human
Immunogen
Recombinant full-length human GNRHR protein.
Host
Rabbit
Clonality
Monoclonal
Clone ID
GNRHR/2982R
Isotype
IgG
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
54-60 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-GnRHR Antibody [GNRHR/2982R] - BSA and Azide free (A251927).
Synonyms
GnRH receptor, GnRH-R, GNRHR1, GNRHR_HUMAN, Gonadotropin releasing hormone receptor, gonadotropin-releasing hormone (type 1) receptor 1, Gonadotropin-releasing hormone receptor, GRHR, HH7, leutinizing-releasing hormone receptor, lh-rh, LHRHR, LRHR, luliberin receptor, luteinizing hormone releasing hormone receptor, type I GnRH receptor
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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