Anti-GRAMD4 Antibody [PCRP-GRAMD4-1A10] (A277610)

Mouse monoclonal [PCRP-GRAMD4-1A10] antibody to GRAMD4 for Flow Cytometry and IF.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-GRAMD4 Antibody [PCRP-GRAMD4-1A10]
Description
Mouse monoclonal [PCRP-GRAMD4-1A10] antibody to GRAMD4.
Specificity
The gene encoding GRAMD4 (GRAM domain-containing protein 4) maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. GRAMD4, also designated death-inducing protein (DIP), is a 578 amino acid mitochondrial membrane protein that acts as an essential mediator of the p53-independent E2F-1 death pathway, which is frequently found to be deregulated in several types of cancers. Overexpression of GRAMD4 results in a strong apoptotic response involving caspase-3 activation and cleavage of poly(ADP-ribose)-polymerase. GRAMD4 is expressed in lung and in primary lung squamous cell carcinoma (LSCC) and shows upregulation in mitochondria by E2F1 after addition of 4-hydroxytamoxifen. This evidence suggests that GRAMD4 may be a potential target for cancer therapies.
Applications
Flow Cytometry, IF
Dilutions
Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml
Reactivity
Human
Cross Reactivity
This antibody is predicted to cross react with Rat.
Immunogen
Recombinant full-length human GRAMD4 protein.
Host
Mouse
Clonality
Monoclonal
Clone ID
PCRP-GRAMD4-1A10
Isotype
IgG1
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
66 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-GRAMD4 Antibody [PCRP-GRAMD4-1A10] - BSA and Azide free (A278198).
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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