Anti-Granzyme A Antibody [GA6] (A280502)

Anti-Granzyme A Antibody [GA6]

Mouse monoclonal [GA6] antibody to Granzyme A.

This antibody recognises Granzyme A, a ~60 kDa disulphide-linked homodimeric protein of two 262 amino acid chains, expressed in cytoplasmic granules of cytotoxic lymphocytes and NK cells.Granzyme A is involved in the induction of apoptosis via its activity as a serine protease, but this would seem to be subsidiary to the role of Granzyme B. Granzyme A deficient mice are indistinguishable from normal animals in their response to infection.Granzyme A has been proposed as a potential biomarker for patients with active tuberculosis with significantly lower levels present in the plasma of patients with the active form of the disease compared to patients with latent infection.

WB, IHC-P

IHC-P 1: 1:50 - 1:200

Human

Recombinant human Granzyme A.

Mouse

Monoclonal

GA6

IgG1

Unconjugated

Protein A affinity chromatography of tissue culture supernatant.

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human granzyme A antibody, clone GA6 recognizes Granzyme A, a ~60 kDa disulphide-linked homodimeric protein of two 262 amino acid chains, expressed in cytoplasmic granules of cytotoxic lymphocytes and NK cells.Granzyme A is involved in the induction of apoptosis via its activity as a serine protease, but this would seem to be subsidiary to the role of Granzyme B. Granzyme A deficient mice are indistinguishable from normal animals in their response to infection.Granzyme A has been proposed as a potential biomarker for patients with active tuberculosis with significantly lower levels present in the plasma of patients with the active form of the disease compared to patients with latent infection (Guggino et al. 2015).

CTL tryptase, CTLA3, Cytolytic t cell and natural killer cell specific trypsin like serine protease, Cytotoxic T lymphocyte associated serine esterase 3, Cytotoxic T lymphocyte proteinase 1, Cytotoxic T-lymphocyte proteinase 1, Fragmentin 1, Fragmentin-1, GRAA_HUMAN, Granzyme 1 cytotoxic T lymphocyte associated serine esterase 3, Granzyme A (Cytotoxic T lymphocyte associated serine esterase 3; Hanukah factor serine protease), Granzyme A (granzyme 1, cytotoxic T lymphocyte associated serine esterase 3), Granzyme A precursor, Granzyme-1, GZMA, H factor, Hanukah factor serine protease, Hanukkah factor, HF, HFSP, TSP1