Anti-Growth Hormone Antibody
|Name:||Anti-Growth Hormone Antibody|
|Description:||Rat monoclonal (KT34) antibody to Growth hormone.|
|Immunogen:||Recombinant human growth hormone.|
|Purification:||IgG is purified through a Protein G column.|
|Formulation:||Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.|
|Storage:||Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.|
|Function:||Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.|
|Involvement in Disease:||Growth hormone deficiency, isolated, 1A: An autosomal recessive, severe deficiency of growth hormone leading to dwarfism. Patients often develop antibodies to administered growth hormone.
Growth hormone deficiency, isolated, 1B: An autosomal recessive deficiency of growth hormone leading to short stature. Patients have low but detectable levels of growth hormone, significantly retarded bone age, and a positive response and immunologic tolerance to growth hormone therapy.
Kowarski syndrome: A syndrome clinically characterized by short stature associated with bioinactive growth hormone, normal or slightly increased growth hormone secretion, pathologically low insulin-like growth factor 1 levels, and normal catch-up growth on growth hormone replacement therapy.
Growth hormone deficiency, isolated, 2: An autosomal dominant deficiency of growth hormone leading to short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy.
|Sequence Similarities:||Belongs to the somatotropin/prolactin family.|
Growth hormone 1 Antibody
Growth hormone, normal Antibody
Growth hormone, pituitary Antibody
Pituitary growth hormone Antibody
|Information:||Target information shown above is from the UniProt Consortium.|