Anti-HDAC3 Antibody [PCRP-HDAC3-2D4] - BSA and Azide free (A278426)

Mouse monoclonal [PCRP-HDAC3-2D4] antibody to HDAC3 for ELISA, IP, Flow Cytometry and IF.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-HDAC3 Antibody [PCRP-HDAC3-2D4] - BSA and Azide free
Description
Mouse monoclonal [PCRP-HDAC3-2D4] antibody to HDAC3.
Specificity
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated RPD3) and HDAC3, all of which are related to the yeast transcriptional factor Rpd3p, have been identified as histone deacetylases.
Applications
ELISA, IP, Flow Cytometry, IF
Dilutions
IP: 1-2µg / 100-500µg proteins, Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant full-length human HDAC3 protein.
Host
Mouse
Clonality
Monoclonal
Clone ID
PCRP-HDAC3-2D4
Isotype
IgG2b
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Molecular Weight
49 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-HDAC3 Antibody [PCRP-HDAC3-2D4] (A277838).
Synonyms
HD3, HDAC 3, HDAC3_HUMAN, Histone deacetylase 3, RPD3, RPD3 2, RPD3-2, SMAP45
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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