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Anti-Hepatitis C Virus Antibody

Total Citations (18)
Mouse monoclonal (B2) antibody to Hepatitis C Virus from Anogen (MO-I40015B).
Name: Anti-Hepatitis C Virus Antibody
Description: Mouse monoclonal (B2) antibody to Hepatitis C Virus.
Specificity: This antibody recognises recombinant core protein C + envelope protein M (residues 1-142 on HCV polyprotein) and synthetic core protein C (residues 1-61 on HCV polyprotein).
Applications: ELISA, WB
Reactivity: Human hepatitis C virus.
Cross Reactivity: This antibody does not recognise recombinant or synthetic HCV non-structural proteins (NS-3 and NS-4).
Immunogen: Synthetic peptides derived from HCV core protein.
Host: Mouse
Clonality: Monoclonal
Clone: B2
Myeloma: Sp2/0-Ag14
Isotype: IgG1
Conjugate: Unconjugated
Concentration: Reconstitution dependent.
Purity: Protein G affinity chromatagraphy.
Product Form: Lyophilised
Reconstitution: Reconstitute with double distilled water.
Formulation: Lyophilised from a solution of 0.01M Phosphate Buffered Saline, pH 7.2.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Introduction: Hepatitis C virus (HCV) causes chronic hepatitis and liver cirrhosis in human through blood and body fluid transmission. HCV has a positive sense single RNA genome enclosed in the nucleocapsid made of Core Protein (Capsid Protein). The nucleocapsid is covered by an envelope made of lipoproteins (E1 and E2). The 9.6 kb HCV genome has a single open-reading frame, which is to be translated into a single polyprotein. HCV viral proteins are produced after processing the polyprotein. Genes for core protein and envelop proteins are located adjacently at the 5’-end of HCV genome, followed by genes for non-structural proteins including NS2, NS3, NS4A, NS4B, NS5, NS5A and NS5B.
Synonyms: Genome polyprotein Antibody
HCV Antibody
Hepatitis C virus polyprotein Antibody

Tiziana Vescovo et al. Autophagy Protects Cells From HCV-Induced Defects in Lipid Metabolism. Gastroenterology Volume 142, Issue 3, Pages 644–653.e3, March 2012.

Troels K.H. Scheel et al. Recombinant HCV Variants With NS5A From Genotypes 1-7 Have Different Sensitivities to an NS5A Inhibitor but Not Interferon-alpha. Gastroenterology Volume 140, Issue 3, Pages 1032–1042. e6, March 2011.

Judith M. Gottwein et al. Novel Infectious cDNA Clones of Hepatitis C Virus Genotype 3a (Strain S52) and 4a (Strain ED43): Genetic Analyses and In Vivo Pathogenesis Studies. Journal of Virology. May 2010; 84(10): 5277-5293.

Candice Jackel-Cram et al. (2010) Hepatitis C virus genotype-3a core protein enhances sterol regulatory element-binding protein-1 activity through the phosphoinositide 3-kinase–Akt-2 pathway. Journal of General Virology, 91:1388–1395.

Takeya Tsutsumi et al. Proteomics analysis of mitochondrial proteins reveals overexpression of a mitochondrial protein chaperon, prohibitin, in cells expressing hepatitis C virus core protein. Hepatology Volume 50, Issue 2, pages 378–386, August 2009.

Hua Liang et al. Differential Effects of Hepatitis C Virus JFH1 on Human Myeloid and Plasmacytoid Dendritic Cells. Journal of Virology. Jun 2009; 83(11): 5693-5707.

Tanja B. Jensen et al. Highly Efficient JFH1-Based Cell-Culture System for Hepatitis C Virus Genotype 5a: Failure of Homologous Neutralizing-Antibody Treatment to Control Infection. Journal of Infectious Diseases. (2008) 198 (12): 1756-1765.

Judith M. Gottwein et al.  Robust Hepatitis C Genotype 3a Cell Culture Releasing Adapted Intergenotypic 3a/2a (S52/JFH1) Viruses. Gastroenterology Volume 133, Issue 5, Pages 1614–1626, November 2007.

Jean-Christophe Meunier et al. Isolation and Characterization of Broadly Neutralizing Human Monoclonal Antibodies to the E1 Glycoprotein of Hepatitis C Virus. Journal of Virology. January 2008 vol. 82 no. 2 966-973.

Akito Sakai et al. In Vivo Study of the HC-TN Strain of Hepatitis C Virus Recovered from a Patient with Fulminant Hepatitis: RNA Transcripts of a Molecular Clone (pHC-TN) Are Infectious in Chimpanzees but Not in Huh7.5 Cells. Journal of Virology. Jul 2007; 81(13): 7208-7219.

Anna R. Ciccaglione et al. Repression of Interferon Regulatory Factor 1 by Hepatitis C Virus Core Protein Results in Inhibition of Antiviral and Immunomodulatory Genes.  Journal of Virology. Jan 2007; 81(1): 202-214.

Hiroki Kawamura et al. HCV core expression in hepatocytes protects against autoimmune liver injury and promotes liver regeneration in mice. Hepatology. Volume 44, Issue 4, pages 936–944, October 2006.

Masaaki Korenaga et al. Hepatitis C Virus Core Protein Inhibits Mitochondrial Electron Transport and Increases Reactive Oxygen Species (ROS) Production. Nov, 2005, The Journal of Biological Chemistry, 280, 37481-37488.

Jiaren Sun et al. Parenchymal Expression of CD86/B7.2 Contributes to Hepatitis C Virus-Related Liver Injury. Journal of Virology. Aug 2005; 79(16): 10730-10739.

Ryosuke Suzuki et al. Molecular Determinants for Subcellular Localization of Hepatitis C Virus Core Protein. Journal of Virology. Jan 2005; 79(2): 1271-1281.

Tsutsumi T et al. Interaction of hepatitis C virus core protein with retinoid X receptor alpha modulates its transcriptional activity. Hepatology. 2002 Apr;35(4):937-46.

Zhang-Xu Liu et al. Hepatitis C Virus Genotype 1b Core Protein Does Not Exert Immunomodulatory Effects on Virus-Induced Cellular Immunity. Journal of Virology. Feb 2002; 76(3): 990-997.

Jiaren Sun et al. Hepatitis C Virus Core and Envelope Proteins Do Not Suppress the Host's Ability To Clear a Hepatic Viral Infection. Journal of Virology. Dec 2001; 75(24): 11992-11998.

Description: Goat polyclonal antibody to Hepatitis C Virus (HCV)
Application: ELISA, IFA, WB, IHC
Host: Goat
Immunogen: Recombinant polypeptide containing core, NS3 and NS4
Product Form: Polyclonal Antibody, purified IgG Fraction

£208





Description: Goat polyclonal antibody to Hepatitis C Virus (HCV)
Application: ELISA, IFA, WB, IHC
Host: Goat
Immunogen: Recombinant E1
Product Form: Polyclonal Antibody, purified IgG Fraction

£208





Description: Goat polyclonal antibody to Hepatitis C Virus (HCV)
Application: ELISA, IFA, WB, IHC
Host: Goat
Immunogen: Recombinant E2
Product Form: Polyclonal Antibody, purified IgG Fraction

£208





Description: Goat polyclonal antibody to Hepatitis C Virus (HCV)
Application: ELISA, IFA, WB, IHC
Host: Goat
Immunogen: Recombinant NS5a + NS5b
Product Form: Polyclonal Antibody, purified IgG Fraction

£208





Please Note: Anti-Hepatitis C Virus Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | MO-I40015B
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