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Anti-HNRNPC Antibody

Rabbit polyclonal antibody to HNRNPC from ABclonal (A0057).
Name: Anti-HNRNPC Antibody
Description: Rabbit polyclonal antibody to HNRNPC.
Applications: WB, IHC
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity: Human
Immunogen: A synthetic peptide of human HNRNPC.
Protein Length: 306
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).
Sequence Similarities: Belongs to the RRM HNRPC family. RALY subfamily.
Post-Translational Modification: Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide.
Cellular Location: Nucleus.

Component of ribonucleosomes.
UniProt: P07910
Gene ID: 3183
Western blot analysis of extracts of various cell lines, using HNRNPC antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Description: Rabbit polyclonal antibody to HNRNPC
Application: WB
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide of human HNRNPC

£234

Description: Rabbit Polyclonal Antibody to HNRNPC
Application: ELISA, WB, IHC, IF, FC
Host: Rabbit
Isotype: IgG
Immunogen: heterogeneous nuclear ribonucleoprotein C (C1/C2)

£241





Please Note: Anti-HNRNPC Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A0057
Size Price Quantity
100µl £243
200µl £372

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Lead Time: Currently 4-6 Days
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe