Anti-HPV16 E1 + E4 Antibody [HPV16 E1/E4] (A251003)

Anti-HPV16 E1 + E4 Antibody [HPV16 E1/E4]

Mouse monoclonal [HPV16 E1/E4] antibody to HPV16 E1 + E4.

The human papilloma virus (HPV) family of DNA tumor viruses includes HPV16, a 'high-risk' sexually-transmitted HPV that can lead to cervical, anal, vulvar, head, neck, and penile cancer. The HPV16E1/E4 protein is expressed abundantly in cells supporting viral DNA amplification, but is lost during malignant progression. HPV16E1/E4 causes G2 cell cycle arrest by associating with and preventing the nuclear entry of Cdk1/cyclin B1 complexes. HPV16E1/E4 also interacts with cyclin A and Cdk2 during the G2 phase of the cell cycle, and this association may increase the efficiency with which HPV16E1/E4 is able to prevent mitotic entry. HPV16E1/E4 also associates with keratin intermediate filaments and causes the network to collapse.

IHC-P: 1-2 µg/ml

HPV-16

Recombinant fragment, around amino acids 36-41, of human HPV16 E1/E4.

Mouse

Monoclonal

HPV16 E1/E4

IgG1

Unconjugated

Protein A/G chromatography.

200 µg/ml

16 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-HPV16 E1 + E4 Antibody [HPV16 E1/E4] - BSA and Azide free (A254182).