Anti-HSP90 alpha Antibody (A283104)

Anti-HSP90 alpha Antibody

Rabbit polyclonal antibody to HSP90 alpha.

This antibody recognises human heat shock protein 90 alpha (HSP90a), one of two HSP90 isoforms together with HSP90ß. These isoforms are encoded by different genes and under normal conditions assist the folding of newly synthesized proteins, and are also important in cellular processes such as hormone signaling and cell cycle control.In response to mutation or environmental stress, HSP90 expression is upregulated as part of the heat shock response, and function to maintain newly destabilized proteins in a folding competent state. HSP90 can also affect the epigenetic state at specific loci, leading to phenotype modulation.Induction of HSP90a by c-Myc may control the activity of multiple signal pathways involved in cellular transformation.

WB, ELISA

ELISA: 1:5,000 - 1:25,000, WB: 1:500 - 1:2500

Human, Monkey, Chicken, Mouse, Drosophila, Rat

Synthetic peptide corresponding to amino acids 289-300 of human heat shock protein 90 alpha.

ELNKTKPIWTRN

Rabbit

Polyclonal

IgG

Unconjugated

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Human heat shock protein 90 alpha antibody detects human heat shock protein 90 alpha (HSP90a), one of two HSP90 isoforms together with HSP90ß. These isoforms are encoded by different genes and under normal conditions assist the folding of newly synthesized proteins, and are also important in cellular processes such as hormone signaling and cell cycle control. In response to mutation or environmental stress, HSP90 expression is upregulated as part of the heat shock response, and function to maintain newly destabilized proteins in a folding competent state. HSP90 can also affect the epigenetic state at specific loci, leading to phenotype modulation. Induction of HSP90a by c-Myc may control the activity of multiple signal pathways involved in cellular transformation.

EL52, epididymis luminal secretory protein 52, Heat shock 86 kDa, heat shock 90kD protein 1, alpha, Heat shock 90kD protein 1, alpha like 4, heat shock 90kD protein, alpha-like 4, Heat shock 90kDa protein 1 alpha, Heat shock protein 90kDa alpha (cytosolic) class A member 1, Heat shock protein HSP 90-alpha, HS90A_HUMAN, HSP 86, HSP86, Hsp89, HSP89A, Hsp90, HSP90A, HSP90AA1, HSP90ALPHA, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, LAP 2, LAP2, lipopolysaccharide-associated protein 2, LPS-associated protein 2, Renal carcinoma antigen NY-REN-38