Anti-ICOS Ligand Antibody [ICOSL/3111] (A248576)

Mouse monoclonal [ICOSL/3111] antibody to ICOS Ligand for ELISA, Flow Cytometry, IF and IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-ICOS Ligand Antibody [ICOSL/3111]
Description
Mouse monoclonal [ICOSL/3111] antibody to ICOS Ligand.
Specificity
This antibody recognizes a protein of 36kDa, identified as ICOS-L. It is a ligand for the ICOS receptor that initiates T and B cell proliferation and cytokine secretion. ICOS-L interactions play an essential role in T cell-dependent B cell activation in peripheral lymphoid organs such as spleen and lymph nodes. ICOS-L protein is present in myeloid leukocytes, and by Northern blot there are 2.4, 3.0, and 7.0 kb transcripts in brain, heart, kidney, and liver, with lower expression in colon and thymus, and a 1.1 kb transcript in leukocytes. Tumor necrosis factor alpha (TNF), granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) enhance its expression. LPS-induced up-regulation of ICOS-L is dependent on the MyD88-dependent signaling pathway.
Applications
ELISA, Flow Cytometry, IF, IHC-P
Dilutions
Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, IHC-P: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment, around amino acids 23-149, of human ICOSLG protein. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
ICOSL/3111
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
36 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-ICOS Ligand Antibody [ICOSL/3111] - BSA and Azide free (A251758).
Synonyms
B7 H2, B7 homolog 2, B7 homologue 2, B7 like protein Gl50, B7 related protein 1, B7-H2, B7-like protein Gl50, B7-related protein 1, B7H2, B7RP 1, B7RP-1, B7RP1, CD 275, CD275, CD275 antigen, GL 50, GL50, ICOS L, ICOS LG, ICOSL, Icoslg, ICOSL_HUMAN, Inducible T cell co stimulator ligand, KIAA0653, LICOS, Transmembrane protein B7 H2 ICOS ligand
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
Publishing research using Anti-ICOS Ligand Antibody [ICOSL/3111] (A248576)? Please let us know so that we can list the citation on this page.

Alternative products to Anti-ICOS Ligand Antibody [ICOSL/3111] (A248576)

Top