Mouse monoclonal (KT133) antibody to IgG3 from Absea Biotechnology (068909H08).
|Description:||Mouse monoclonal (KT133) antibody to IgG3.|
|Purification:||IgG is purified through a Protein A column.|
|Concentration:||1 mg/ml in PBS containing 0.09% sodium azide as a preservative.|
|Storage:||4 °C for 1 month, -20 °C or -80°C in aliquots. Avoid repeated freeze/thaw cycles.|
|Function:||Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).|
|Cellular Location:||Secreted. Cell membrane.|
Heavy chain disease protein Antibody
Ig gamma 3 chain C region Antibody
Immunoglobulin heavy constant gamma 3 (G3m marker) Antibody
|Information:||Target information shown above is from the UniProt Consortium.|
ELISA using plates coated with human antibodies with various isotypes.
Sandwich ELISA for purified IgG3 using KT133 coated plate and HRP conjugated KT131.
Sandwich ELISA for normal human serum samples.
Please Note: Anti-IgG3 Antibody is for research use only. It is not intended for diagnostic of therapeutic use.