Mouse monoclonal (KT130) antibody to IgG4 from Absea Biotechnology (068709G12).
|Description:||Mouse monoclonal (KT130) antibody to IgG4.|
|Purification:||IgG is purified through a Protein A column.|
|Concentration:||1 mg/ml in PBS containing 0.09% sodium azide as a preservative.|
|Storage:||4 °C for 1 month, -20 °C or -80°C in aliquots. Avoid repeated freeze/thaw cycles.|
|Function:||Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).|
|Cellular Location:||Secreted. Cell membrane.|
|Synonyms:||Ig gamma 4 chain C region Antibody
Immunoglobulin heavy constant gamma 4 (G4m marker) Antibody
|Information:||Target information shown above is from the UniProt Consortium.|
ELISA using plates coated with human antibodies with various isotypes.
Western blotting using purified IgG4 under reducing conditions.
Sandwich ELISA for purified IgG4.
Sandwich ELISA for normal human serum samples using KT130 coated plate and HRP conjugated KT132.
Please Note: Anti-IgG4 Antibody is for research use only. It is not intended for diagnostic of therapeutic use.