Anti-IL-1 beta Antibody [IL1B/4651] - BSA and Azide free (A316526)

$765

Mouse monoclonal [IL1B/4651] antibody to IL-1 beta for ELISA and IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-IL-1 beta Antibody [IL1B/4651] - BSA and Azide free
Description
Mouse monoclonal [IL1B/4651] antibody to IL-1 beta.
Specificity
Recognizes a protein of 17-31kDa, identified as interleukin 1beta. It shows no cross-reaction with interleukin 1alpha. Epitopes of MAb IL1B/463 and IL1B/4651 are different and provide a good pair for developing an ELISA. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
Applications
ELISA, IHC-P
Positive Control
LPS stimulated human peripheral blood mononuclear cells. Human adrenal gland, colon or liver tissue.
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment (around Amino Acids 100-269) of human IL1B protein. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
IL1B/4651
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Molecular Weight
31 kDa (proprotein) / 17 kDa (mature)
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
Catabolin, H1, Hematopoietin 1 , IFN beta inducing factor , IL 1 , IL 1 beta , IL 1B, IL 1beta, IL1 , IL1 beta, IL1B, IL1B_HUMAN, IL1F2 , Interleukin 1 beta , Interleukin 1 beta precursor , Interleukin-1 beta, LAF, OAF, Osteoclast activating factor , OTTHUMP00000162031, Preinterleukin 1 beta, Preinterleukin beta , Pro interleukin 1 beta
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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