Anti-IL-3 Antibody [IL3/4003] (A315176)

Anti-IL-3 Antibody [IL3/4003]

Mouse monoclonal [IL3/4003] antibody to IL-3.

Interleukin-3, or IL-3, is a pleiotropic cytokine that is primarily secreted by activated T lymphocytes and stimulates the proliferation and differentiation of hematopoietic cells. IL-3 not only supports growth of both pluripotent stem cells and the more differentiated committed progenitors, but it also stimulates the functional activity of some fully differentiated cells. IL-3 has also been shown to protect mast cells from undergoing apoptosis. IL-3 exerts its biological effects through a receptor which consists of a ligand-specific subunit has been shown to be necessary for activation of the MAP kinase signaling pathway. Although the IL-3 receptor has no intrinsic kinase activity, stimulation with IL-3 leads to tyrosine phosphorylation of the JAK/Tyk 2 family member, JAK2, which in turn activates and causes nuclear translocation of Stat5a and Stat5b.

Human thymus or tonsil tissue.

IHC: 1-2 µg/ml

Human

Recombinant fragment of human IL3 protein. The exact sequence is proprietary.

Mouse

Monoclonal

IL3/4003

IgG1

Unconjugated

Protein A/G chromatography.

200 µg/ml

17 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Burst promoting activity, Colony stimulating factor multiple, Eosinophil colony stimulating factor, Hematopoietic growth factor, IL 3, IL3, IL3_HUMAN, Interleukin 3, Interleukin 3 (colony stimulating factor, multiple), Interleukin-3, Mast cell growth factor, MCGF, MGC79398, MGC79399, Multi CSF, Multilineage colony stimulating factor , Multipotential colony stimulating factor , Multipotential colony-stimulating factor, OTTHUMP00000065963, P cell stimulating factor , P-cell-stimulating factor, Thy1 inducing factor