Anti-Integrin beta 3 Antibody (FITC)
Rabbit polyclonal antibody to Integrin beta 3 (FITC) from FabGennix (INTGB3-FITC).
|Name:||Anti-Integrin beta 3 Antibody (FITC)|
|Description:||Rabbit polyclonal antibody to Integrin beta 3 (FITC)|
|Applications:||ELISA, IHC, IP, WB|
|Dilutions:||DB: 1:10,000; ELISA: 1:10,000; Immunoprecipitation: 1:150; Western Blot: 1:500|
|Immunogen:||Synthetic peptide taken within amino acid region 1-50 on human Integrin Beta 3 subunit protein.|
|Concentration:||0.55-0.75 µg/µl in antibody stabilization buffer|
|Storage:||-20⁰C for long term storage|
|Function:||Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887).|
|Tissue Specificity:||Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.|
|Involvement in Disease:||Glanzmann thrombasthenia: A common inherited disease of platelet aggregation. It is characterized by mucocutaneous bleeding of mild-to-moderate severity. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at reduced levels, have detectable amounts of fibrinogen, and have low or moderate clot retraction capability.
Bleeding disorder, platelet-type 16: An autosomal dominant form of congenital macrothrombocytopenia associated with platelet anisocytosis. It is a disorder of platelet production. Affected individuals may have no or only mildly increased bleeding tendency. In vitro studies show mild platelet functional abnormalities.
|Sequence Similarities:||Belongs to the integrin beta chain family.|
|Post-Translational Modification:||Phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Probably involved in outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both Tyr-773 and Tyr-785 are phosphorylated. Phosphorylation of Thr-779 inhibits SHC binding.|
|Cellular Location:||Cell membrane. Cell projection > Lamellipodium membrane. Cell junction > Focal adhesion.|
CD 61 Antibody
CD61 antigen Antibody
HPA 1 Antibody
HPA 4 Antibody
Integrin beta 3 (platelet glycoprotein IIIa antigen CD61) Antibody
Integrin beta chain beta 3 Antibody
Integrin beta-3 Antibody
ITG B3 Antibody
ITGB 3 Antibody
Platelet fibrinogen receptor beta subunit Antibody
Platelet fibrinogen receptor, beta subunit Antibody
Platelet glycoprotein IIIa Antibody
Platelet glycoprotein IIIa precursor Antibody
Platelet membrane glycoprotein IIIa Antibody
|Information:||Target information shown above is from the UniProt Consortium.|
Please Note: Anti-Integrin beta 3 Antibody (FITC) is for research use only. It is not intended for diagnostic of therapeutic use.