Anti-Integrin beta 3 Antibody [HM beta 3.1] (PE) (A280611)

Anti-Integrin beta 3 Antibody [HM beta 3.1] (PE)

Hamster monoclonal [HM beta 3.1] antibody to Integrin beta 3 (PE).

This antibody recognises the murine integrin beta 3 subunit (CD61), a ~90 kDa a type I membrane protein, expressed primarily on megakaryocytes, platelets, monocytes, macrophages, granulocytes and endothelial cells. CD61 associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) to form the platelet glycoprotein complex IIb/IIIa and the vitronectin receptor (VNR) respectively. The heterodimers formed with CD61 are receptor for a variety of ligands including fibrinogen, fibronectin, von Willebrands factor (vWF), vitronectin and thrombospondin.Hamster anti Mouse CD61 antibody, clone HM beta 3-1 is reported to partially inhibit the binding of CD61 to fibronectin.

Flow Cytometry: Neat - 1:10, Use 10µl of the suggested working dilution to label 10⁶ cells in 100µl. The Fc region of monoclonal antibodies may bind to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR (BUF041A/BUF041B).

Mouse, Rat

Mouse alpha 5 beta 3 protein purified from the mouse hybridoma 2B4.

Hamster

Monoclonal

HM beta 3.1

IgG

Protein G affinity chromatography of tissue culture supernatant.

Reconstitution dependent.

Lyophilized

Reconstitute with 1 ml of distilled water.

Supplied in Phosphate Buffered Saline with 1% BSA, 5% Sucrose, and 0.09% Sodium Azide.

Store undiluted at 4°C. Do not freeze! This product is photosensitive and should be protected from light.

Hamster anti Mouse CD61 antibody, clone HM beta 3-1 recognizes the murine integrin beta 3 subunit (CD61), a ~90 kDa a type I membrane protein, expressed primarily on megakaryocytes, platelets, monocytes, macrophages, granulocytes and endothelial cells. CD61 associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) to form the platelet glycoprotein complex IIb/IIIa and the vitronectin receptor (VNR) respectively. The heterodimers formed with CD61 are receptor for a variety of ligands including fibrinogen, fibronectin, von Willebrands factor (vWF), vitronectin and thrombospondin.Hamster anti Mouse CD61 antibody, clone HM beta 3-1 is reported to partially inhibit the binding of CD61 to fibronectin (Yasuda et al. 1995).

BDPLT16, BDPLT2, CD 61, CD61, CD61 antigen, GP3A, GPIIIa, GT, HPA 1, HPA 4, Integrin beta 3 (platelet glycoprotein IIIa antigen CD61), Integrin beta chain beta 3, Integrin beta-3, ITB3_HUMAN, ITG B3, ITGB 3, ITGB3, NAIT, Platelet fibrinogen receptor beta subunit, Platelet fibrinogen receptor, beta subunit, Platelet glycoprotein IIIa, Platelet glycoprotein IIIa precursor, Platelet membrane glycoprotein IIIa, PTP

This product is for research use only. It is not intended for diagnostic or therapeutic use.