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Anti-IP3 receptor Antibody (Biotin)

 
Rabbit polyclonal antibody to IP3 receptor (Biotin) from FabGennix (ITPR1-BIOTIN).
Overview
Name: Anti-IP3 receptor Antibody (Biotin)
Description: Rabbit polyclonal antibody to IP3 receptor (Biotin)
Applications: ELISA, WB
Dilutions: DB: 1:10,000; ELISA: 1:10,000; Western Blot: 1:500
Reactivity: Bovine, Human, Monkey, Mouse, Rat
Immunogen: Synthetic peptide corresponding to unique amino acid sequence on human ITPR subtype 1 protein.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Biotin
Concentration: 0.52-0.63 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target
Function: Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).
Tissue Specificity: Widely expressed.
Involvement in Disease: Spinocerebellar ataxia 15: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA15 is an autosomal dominant cerebellar ataxia (ADCA). It is very slow progressing form with a wide range of onset, ranging from childhood to adult. Most patients remain ambulatory.

Spinocerebellar ataxia 29: An autosomal dominant, congenital spinocerebellar ataxia characterized by early motor delay, hypotonia and mild cognitive delay. Affected individuals develop a very slowly progressive or non-progressive gait and limb ataxia associated with cerebellar atrophy on brain imaging. Additional variable features include nystagmus, dysarthria, and tremor.

Gillespie syndrome: A rare disease characterized by bilateral iris hypoplasia, congenital hypotonia, non-progressive ataxia, progressive cerebellar atrophy, and mental retardation.
Sequence Similarities: Belongs to the InsP3 receptor family.
Post-Translational Modification: Phosphorylated on tyrosine residues.
Cellular Location: Endoplasmic reticulum membrane. Cytoplasmic vesicle > Secretory vesicle membrane. Cytoplasm > Perinuclear region.

Endoplasmic reticulum and secretory granules (By similarity).
UniProt: Q14643
Synonyms: 4 Antibody
5-trisphosphate receptor Antibody
5-trisphosphate receptor type 1 Antibody
5-trisphosphate receptor type 3 Antibody
DKFZp313E1334 Antibody
DKFZp313N1434 Antibody
FLJ36205 Antibody
Inositol 1 Antibody
inositol 1 4 5 triphosphate receptor type 1 Antibody
Inositol 1 4 5 trisphosphate Receptor Type 1 Antibody
Inositol 1 4 5 trisphosphate receptor type 2 Antibody
Inositol 1,4,5 trisphosphate receptor type 3 Antibody
Inositol 1,4,5-trisphosphate receptor type 2 Antibody
Inositol 145 trisphosphate receptor type 2 Antibody
InsP3 R2 Antibody
InsP3R1 Antibody
InsP3R2 Antibody
InsP3R3 Antibody
IP3 Antibody
IP3 R2 Antibody
IP3 receptor isoform 1 Antibody
IP3 receptor isoform 2 Antibody
IP3 receptor isoform 3 Antibody
IP3R Antibody
IP3R 1 Antibody
IP3R 2 Antibody
IP3R 3 Antibody
IP3R1 Antibody
IP3R2 Antibody
IP3R3 Antibody
ITPR 1 Antibody
ITPR 2 Antibody
ITPR 3 Antibody
Itpr1 Antibody
ITPR1_HUMAN Antibody
ITPR2 Antibody
ITPR2_HUMAN Antibody
ITPR3 Antibody
ITPR3_HUMAN Antibody
SCA15 Antibody
SCA16 Antibody
SCA29 Antibody
Type 1 inositol 1 Antibody
Type 1 inositol 1 4 5 trisphosphate receptor Antibody
Type 1 InsP3 receptor Antibody
Type 2 inositol 1 Antibody
Type 2 inositol 1 4 5 trisphosphate receptor Antibody
Type 2 inositol 145 trisphosphate receptor Antibody
Type 2 InsP3 receptor Antibody
Type 3 inositol 1 Antibody
Type 3 inositol 1,4,5 trisphosphate receptor Antibody
Type 3 InsP3 receptor Antibody
Information: Target information shown above is from the UniProt Consortium.


Please Note: Anti-IP3 receptor Antibody (Biotin) is for research use only. It is not intended for diagnostic of therapeutic use.
Antibodies.com | ITPR1-BIOTIN
Size Price Quantity
100µg £429

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