Anti-IRE1p Antibody (A283000)

Anti-IRE1p Antibody

Rabbit anti IRE1p (C-Terminal)

Rabbit anri IRE1p antibody recognizes the C-terminus of inositol-requiring kinase 1 precursor (IRE1p), a 108 kDa serine-threonine kinase/endoribonuclease also known as ERN1. It is an endoplasmic reticulum (ER) transmembrane protein, normally bound to the ER molecular chaperones GRP78 and GRP94. At times of ER stress, due to accumulation of unfolded proteins, IRE1p becomes dissociated from the chaperones, which allows it to activate the un-folded protein transcriptional response (UPR). In the mammalian genome, there are two homologs Ire1alpha and Ire1beta. Ire1alpha is expressed in all cells and tissues, Ire1beta expression is primarily restricted to intestinal epithelial cells.

WB, IHC-Fr

Human, Rat, Mouse

A 16 amino acid peptide near the carboxy terminus of human IRE1p.

Rabbit

Polyclonal

IgG

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Endoplasmic reticulum (ER) to nucleus signalling 1, Endoplasmic reticulum to nucleus signaling 1, Endoplasmic reticulum-to-nucleus signaling 1, Endoribonuclease, ER to nucleus signaling 1, ERN 1, Ern1, ERN1_HUMAN, hIRE 1p, hIRE1p, Inositol requiring 1, Inositol requiring 1, S. cerevisiae, homolog of, Inositol requiring enzyme 1, S. cerevisiae, homolog of, Inositol requiring protein 1, inositol-requiring enzyme 1, Inositol-requiring protein 1, IRE 1, IRE 1a, IRE 1P, IRE1, Ire1 alpha, Ire1-alpha, IRE1a, Ire1alpha, MGC163277, MGC163279, Protein kinase/endoribonuclease, RGD1559716, Serine/threonine protein kinase/endoribonuclease IRE1