Anti-IRF3 Anticorpo [3F10] (A279303)

$340

Anticorpo monoclonale [3F10] di topo contro IRF3 per ELISA, WB e IP.

Spese di spedizione
Tempi di consegna
4-6 Giorni lavorativi
Telefono
+1 (314) 370-6046
Lun - Ven, 8:00 - 16:00 AST
E-mail
orders@antibodies.com
Nome
Anti-IRF3 Antibody [3F10]
Descrizione
Mouse monoclonal [3F10] antibody to IRF3.
Specificità
This antibody recognises human interferon regulatory factor 3 (IRF3), a ~55 kDa constitutively expressed member of the IRF family, which acts as vital regulator of gene expression in innate immunity. IRF3 accumulates in an inactive form in the cytoplasm and then translocates to the nucleus as a homodimer, following stimuli-induced phosphorylation of specific serine/threonine residues. Association of the homodimer with p300/CBP (CREBB binding protein) forms dsRNA-activated factor 1 (DRAF1), which then activates the transcription of interferon alpha and beta and subsequent downstream interferon-induced genes.
Applicazioni
ELISA, WB, IP
Diluizioni consigliate
WB: 1:1,000 - 1:3,000
Reattività
Human
Immunogeno
Recombinant human IRF3 (amino acids 108-166) purified from E. coli.
Sequenza
EFVNSGVGDFSQPDTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEP
Specie ospite
Mouse
Clonalità
Monoclonal
Clona ID
3F10
Isotipo
IgG1
Coniugare

Unconjugated

Purificazione
Protein G affinity chromatography of ascites.
Concentrazione
1 mg/ml
Peso molecolare
Approximately 55 kDa in HeLa cell lysates.
Forma del prodotto
Liquid
Formulazione
Supplied in Phosphate Buffered Saline with 0.01% Sodium Azide and 10% Glycerol.
Conservazione
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
Note generali
Mouse anti Human IRF3 antibody, clone 3F10 recognizes human interferon regulatory factor 3 (IRF3), a ~55 kDa constitutively expressed member of the IRF family, which acts as vital regulator of gene expression in innate immunity (Nociari et al. 2007).IRF3 accumulates in an inactive form in the cytoplasm and then translocates to the nucleus as a homodimer, following stimuli-induced phosphorylation of specific serine/threonine residues. Association of the homodimer with p300/CBP (CREBB binding protein) forms dsRNA-activated factor 1 (DRAF1), which then activates the transcription of interferon alpha and beta and subsequent downstream interferon-induced genes (Weaver et al. 1998).
Sinonimi
IIAE7, Interferon regulatory factor 3, IRF 3, IRF-3, IRF3_HUMAN, MGC94729
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

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