CD89 è un gene codificato dal simbolo FCAR. Altri nomi includono: Immunoglobulin alpha Fc receptor; IgA Fc receptor; FCAR. CD89 ha una massa di 32.27kDa e una lunghezza di amminoacidi di 287.
Offriamo 13 anticorpi contro CD89, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo e Primati.
Informazioni su geni e proteine
Riepilogo UniProt
Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.
Sommario di Entrez
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Specificità del tessuto
Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces.
Posizione cellulare
Cell membrane.
