Cytokeratin 7 è un gene codificato dal simbolo KRT7. Altri nomi includono: Keratin, type II cytoskeletal 7; Cytokeratin-7; CK-7; Keratin-7; K7; Sarcolectin; Type-II keratin Kb7; KRT7; SCL. Cytokeratin 7 ha una massa di 51.39kDa e una lunghezza di amminoacidi di 469.
Offriamo 60 anticorpi contro Cytokeratin 7, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo, Ratto, Cane, Gatto, Criceto e Zebrafish.
Informazioni su geni e proteine
Riepilogo UniProt
Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).
Sommario di Entrez
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described.
Specificità del tessuto
Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus.
Somiglianze di sequenza
Belongs to the intermediate filament family.
Modifica post-translazionale
Arg-20 is dimethylated, probably to asymmetric dimethylarginine.
Posizione cellulare
Cytoplasm.
