Histone H3 è un gene codificato dal simbolo H3-IX. Comunemente indicato anche come: Histone H3.3; H3-IX. Histone H3 ha una massa di 15.33kDa, una lunghezza di amminoacidi di 136, ed è implicato in Glioma.
Offriamo 224 anticorpi contro Histone H3, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF, IP, Dot e ChIP con campioni derivati da Umano, Topo, Ratto, Scimmia e Zebrafish.
Informazioni su geni e proteine
Riepilogo UniProt
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Sommario di Entrez
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This histone pseudogene is found in the large histone gene cluster on chromosome 6.
Specificità del tessuto
Low levels of expression in ovaries and moderate levels of expression in the testes. Highest levels of expression in embryos.
Coinvolgimento nella malattia
Glioma: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.
Somiglianze di sequenza
Belongs to the histone H3 family.
Modifica post-translazionale
Acetylation is generally linked to gene activation.
Posizione cellulare
Nucleus. Chromosome.