LIME è un gene codificato dal simbolo LIME1. Comunemente indicato anche come: Lck-interacting transmembrane adapter 1; Lck-interacting membrane protein; Lck-interacting molecule1. LIME ha una massa di 31.29kDa e una lunghezza di amminoacidi di 295.
Offriamo 7 anticorpi contro LIME, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA, Citometria a Flusso e IP con campioni derivati da Umano e Topo.
Informazioni su geni e proteine
Riepilogo UniProt
Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.
Sommario di Entrez
This gene encodes a transmembrane adaptor protein that links the T and B-cell receptor stimulation to downstream signaling pathways via its association with the Src family kinases Lck and Lyn, respectively. Alternative splicing of this gene results in multiple transcript variants.
Specificità del tessuto
Expressed in peripheral blood lymphocytes, lymphoid tissues, and liver. Present in T-cells and plasma cells, and in various hematopoietic cell lines (at protein level).
Modifica post-translazionale
Palmitoylation of Cys-28 and Cys-31 is required for raft targeting.
Posizione cellulare
Cell membrane.
Present in lipid rafts. Recruited to the immunological synapse upon conjugation of T-cell with antigen-presenting cell.
