Tollip è un gene codificato dal simbolo TOLLIP. È noto anche come Toll-interacting protein. Tollip ha una massa di 30.28kDa e una lunghezza di amminoacidi di 274.
Offriamo 9 anticorpi contro Tollip, allevati nel Coniglio, Topo e Ratto, che sono adatti per WB, IHC, ICC/IF e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851).
Sommario di Entrez
This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. Several transcript variants encoding different isoforms have been found for this gene.
Somiglianze di sequenza
Belongs to the tollip family.
Modifica post-translazionale
Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products.
Posizione cellulare
Cytoplasm.
