This antibody recognises Toll-interacting protein (TOLLIP), an ubiquitin binding protein that plays an important role in regulating the innate immune response.TOLLIP, as the name implies, interacts with a number of Toll-like receptors thereby mediating the regulation of the autophagic clearance and NF-kappaB pathways. The latter pathway, TOLLIP mainly regulates through controlling phosphorylation levels of the IRAK1 kinase. TOLLIP deficiencies have been implicated in increased tuberculosis susceptibility.
Applicazioni
WB, IP
Diluizioni consigliate
WB: 5 µg/ml
Reattività
Mouse, Human
Immunogeno
Recombinant mouse TOLLIP.
Specie ospite
Rat
Clonalità
Monoclonal
Clona ID
Kimmy-1
Isotipo
IgG2a
Coniugare
Unconjugated
Concentrazione
1 mg/ml
Peso molecolare
Approximately 30 kDa by Western Blot.
Forma del prodotto
Liquid
Formulazione
Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.
Conservazione
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
Note generali
Rat anti TOLLIP antibody clone Kimmy-1 recognizes Toll-interacting protein (TOLLIP), an ubiquitin binding protein that plays an important role in regulating the innate immune response.TOLLIP, as the name implies, interacts with a number of Toll-like receptors thereby mediating the regulation of the autophagic clearance and NF-kappaB pathways. The latter pathway, TOLLIP mainly regulates through controlling phosphorylation levels of the IRAK1 kinase. TOLLIP deficiencies have been implicated in increased tuberculosis susceptibility (Sha et al. 2012).
Sinonimi
Adapter protein, FLJ33531, IL 1RAcPIP, IL1RAcPIP, TOLIP, TOLIP_HUMAN, Toll interacting protein, Toll-interacting protein
