|Description:||Rabbit polyclonal antibody to ITGB4.|
|Dilutions:||WB: 1:500 - 1:2000.|
|Immunogen:||Recombinant protein of human ITGB4.|
|Formulation:||Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.|
|Storage:||Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.|
|Function:||Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760).|
|Tissue Specificity:||Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.|
|Involvement in Disease:||Epidermolysis bullosa letalis, with pyloric atresia: An autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.
Generalized atrophic benign epidermolysis bullosa: A non-lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities.
|Sequence Similarities:||Belongs to the integrin beta chain family.|
|Post-Translational Modification:||Palmitoylated by DHHC3 at several cysteines of the membrane-proximal region, enhancing stability and cell surface expression. Palmitoylation also promotes secundary association with tertaspanins.|
|Cellular Location:||Cell membrane. Cell membrane. Cell junction > Hemidesmosome.
Colocalizes with DST at the leading edge of migrating keratinocytes.
|Synonyms:||CD 104 Antibody
CD104 antigen Antibody
Integrin beta 4 Antibody
Integrin beta 4 subunit Antibody
Integrin beta-4 Antibody
ITG B4 Antibody
ITGB 4 Antibody
|Information:||Target information shown above is from the UniProt Consortium.|