+44 (0)1223 298875

Anti-ITGB4 Antibody

Rabbit polyclonal antibody to ITGB4 from ABclonal (A0857).
Name: Anti-ITGB4 Antibody
Description: Rabbit polyclonal antibody to ITGB4.
Applications: WB
Dilutions: WB: 1:500 - 1:2000.
Reactivity: Human
Immunogen: Recombinant protein of human ITGB4.
Protein Length: 1822
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760).
Tissue Specificity: Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.
Involvement in Disease: Epidermolysis bullosa letalis, with pyloric atresia: An autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.

Generalized atrophic benign epidermolysis bullosa: A non-lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities.
Sequence Similarities: Belongs to the integrin beta chain family.
Post-Translational Modification: Palmitoylated by DHHC3 at several cysteines of the membrane-proximal region, enhancing stability and cell surface expression. Palmitoylation also promotes secundary association with tertaspanins.
Cellular Location: Cell membrane. Cell membrane. Cell junction > Hemidesmosome.

Colocalizes with DST at the leading edge of migrating keratinocytes.
UniProt: P16144
Gene ID: 3691
Synonyms: CD 104 Antibody
CD104 Antibody
CD104 antigen Antibody
gp150 Antibody
Integrin beta 4 Antibody
Integrin beta 4 subunit Antibody
Integrin beta-4 Antibody
ITB4_HUMAN Antibody
ITG B4 Antibody
ITGB 4 Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of extracts of MCF7 cells lines, using ITGB4 antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Description: Rabbit polyclonal antibody to ITGB4 (Ab-1510)
Application: WB, IHC
Host: Rabbit
Reactivity: Human
Immunogen: Synthesized non-phosphopeptide derived from human ITGB4 around the phosphorylation site of tyrosine 1510 (R-D-Y(p)-S-T).

£180 – £234

Description: Rabbit polyclonal antibody to ITGB4 (Phospho-Tyr1510)
Application: WB, IHC
Host: Rabbit
Reactivity: Human
Immunogen: Peptide sequence around phosphorylation site of tyrosine1510(R-D-Y(p)-S-T) derived from Human ITGB4 .

£180 – £234

Please Note: Anti-ITGB4 Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A0857
Size Price Quantity
50µl £148
100µl £243
200µl £372

Request a quotation
Contact Us Directly
  • call icon + 44 (0)1223 298 875
  • + 44 (0)1223 281 447
  • email icon info@antibodies.com
Product Quality
  • guarantee icon
  • We promise guaranteed product quality
  • and expert customer service.
Lead Time: Currently 4-6 Days
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe