Anti-Kappa Light Chain Antibody [KLC264] (CF® 488) (A251136)

Anti-Kappa Light Chain Antibody [KLC264] (CF® 488)

Mouse monoclonal [KLC264] antibody to Kappa Light Chain (CF® 488).

This antibody is specific to kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkins lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.

Flow Cytometry, IF

Flow Cytometry: 5 µl / million cells or 5 µl / 100 µl whole blood, IF: 1:50-1:100

Human

Recombinant human Ig kappa chain.

Mouse

Monoclonal

IgG1

kappa

CF® 488

Excitation: 490nm, Emission: 515nm

Protein A/G chromatography.

100 µg/ml

~22.5 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Store at 4-8°C. Antibody is stable for 24 months.

HCAK 1, HCAK1, Ig kappa chain C region, IGKC, IGKCD, Immunoglobulin InV, Immunoglobulin kappa constant, Immunoglobulin kappa constant region, Immunoglobulin kappa light chain, Immunoglobulin kappa light chain constant region, Immunoglobulin KM, Kappa 1 immunoglobulin light chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809

This product is for research use only. It is not intended for diagnostic or therapeutic use.